Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration

    September 2023 in “ Nature Communications ”
    YANG YANG, Chenyu Chu, Li Liu, Chenbing Wang, Changwei Hu, Shengan Rung, Yi Man, Yang Qu
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    TLDR Immune cells are essential for skin regeneration using biomaterial scaffolds.
    The study "Tracing immune cells around biomaterials with spatial anchors during large-scale wound regeneration" investigates the role of immune cells and fibroblasts in wound healing and hair follicle regeneration. The researchers found that macrophages and T cells play crucial roles in tissue repair and hair follicle regeneration. They also discovered that a biomaterial scaffold can accelerate the healing process and promote hair follicle regeneration without triggering any obvious fibrous capsule. The study identified different subsets of fibroblasts and immune cells, including neutrophils and T regulatory cells, that contribute to the wound healing process. The researchers concluded that the adaptive immune system is required for skin regeneration mediated by extracellular matrix scaffolds. The study did not mention the number of participants involved.
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