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research Tenascin-C and tenascin-W in whisker follicle stem cell niches: possible roles in regulating stem cell proliferation and migration

25 citations , January 2013 in “Journal of Cell Science”

The study investigated the roles of glycoproteins tenascin-C and tenascin-W in the stem cell niches of mouse whisker follicles. CD34-positive stem cells migrate from their niche to the whisker bulb, contributing to whisker shaft formation. Tenascin-C was found in the fibrous capsule, glassy membrane, and trabecular region, while tenascin-W was present in the stem cell niche, nearby trabeculae, and neural stem cell niche of hair follicles. Both glycoproteins inhibited stress fiber and focal adhesion complex formation in cultured stem cells, suggesting they promote cell migration. Additionally, tenascin-C increased stem cell proliferation in vitro, indicating that these glycoproteins may regulate stem cell migration and proliferation in whisker follicles.

research Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration

September 2023 in “Nature Communications”

Immune cells are essential for skin regeneration using biomaterial scaffolds.

research Histopathological Examination of Hair Matrix Cysts

May 2020 in “International journal of dermatology and venereology”

Hair matrix cysts are rare skin nodules with unique features, often needing surgical removal.

research Histology, Lectin Histochemistry, and Ultrastructure of Interdigital Gland in Crossbred Sheep

3 citations , December 2020

The interdigital gland in crossbred sheep is similar to skin and has specialized structures for secretion.

research Biocompatibility Of Kaps-Depleted Residual Hair

May 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

KAP-depleted hair causes less immune response and is more biocompatible for implants.

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community I have a hard time believing that creatine overpowers fin/dut

in Finasteride/Dutasteride 109 upvotes 2 years ago

The conversation is about whether creatine causes hair loss in individuals who are taking finasteride or dutasteride for hair loss. Some users report experiencing hair loss when taking creatine, while others do not. There is no consensus on the issue.

community "Hair Follicle Stem Cells are quiescent 99% of the time and permanently reside in the hair follicle"

in Research/Science 1389 upvotes 2 months ago

Hair follicles are mostly dormant but can be reactivated with treatments like minoxidil, finasteride, and microneedling. A new drug, PP405, shows promise for hair regrowth but may not be available until 2027-2028.

community Sugar and Hair loss connections

in Research/Science 41 upvotes 5 months ago

High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.

community How dutasteride makes hair loss impossible

in Chat 142 upvotes 8 months ago

Dutasteride is discussed as a treatment that makes hair loss impossible, with some users sharing experiences of hair regrowth and side effects. Finasteride and oral minoxidil are also mentioned as treatments, with concerns about side effects and effectiveness.

community How a follicle next to it is so genetically different that it never miniaturized??

in Chat 219 upvotes 1 month ago

Genetic differences in hair follicles affect hair loss patterns. Treatments discussed include finasteride, dutasteride, minoxidil, and RU58841.

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