Tenascin-C and Tenascin-W in Whisker Follicle Stem Cell Niches: Possible Roles in Regulating Stem Cell Proliferation and Migration

    January 2013 in “ Journal of Cell Science ”
    Richard P. Tucker, Jacqueline Ferralli, Johannes C. Schittny, Ruth Chiquet‐Ehrismann
    Studysummary This study suggests that glycoproteins tenascin-C and tenascin-W may influence the migration and proliferation of CD34-positive stem cells in mouse whisker follicles.
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    The study investigated the roles of glycoproteins tenascin-C and tenascin-W in the stem cell niches of mouse whisker follicles. CD34-positive stem cells migrate from their niche to the whisker bulb, contributing to whisker shaft formation. Tenascin-C was found in the fibrous capsule, glassy membrane, and trabecular region, while tenascin-W was present in the stem cell niche, nearby trabeculae, and neural stem cell niche of hair follicles. Both glycoproteins inhibited stress fiber and focal adhesion complex formation in cultured stem cells, suggesting they promote cell migration. Additionally, tenascin-C increased stem cell proliferation in vitro, indicating that these glycoproteins may regulate stem cell migration and proliferation in whisker follicles.
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