An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice

April 2023 in “ Science Advances ”

Antonio Tomasso, Tim Koopmans, Philip Lijnzaad, Kerstin Bartscherer, Ashley W. Seifert

ERK extracellular signal-regulated kinase fibrosis regeneration fibroblast growth factor ErbB signaling cell proliferation extracellular matrix remodeling hair follicle neogenesis FGF ErbB cell growth ECM remodeling hair follicle formation

Studysummary This study found that sustained ERK activity during tissue regeneration in spiny mice is linked to fibroblast growth factor and ErbB signaling, while inhibiting ERK shifted regeneration toward scarring.

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