An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice

    April 2023 in “ Science Advances ”
    Antonio Tomasso, Tim Koopmans, Philip Lijnzaad … Ashley W. Seifert
    Studysummary This study found that sustained ERK activity during tissue regeneration in spiny mice is linked to fibroblast growth factor and ErbB signaling, while inhibiting ERK shifted regeneration toward scarring.
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    Research cited in this study 8

    1. Adult Spiny Mice (Acomys) Exhibit Endogenous Cardiac Recovery in Response to Myocardial Infarction npj Regenerative Medicine · 2021
    2. Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice Nature Communications · 2021
    3. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    4. The Blastema and Epimorphic Regeneration in Mammals Developmental Biology · 2017
    5. Concise Review: Translating Regenerative Biology Into Clinically Relevant Therapies: Are We on the Right Path? Stem Cells Translational Medicine · 2017
    6. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    7. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    8. Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys) Nature · 2012