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GlossaryExtracellular Matrix Remodeling (ECM Remodeling)

continuous restructuring of the protein network outside cells

Extracellular Matrix Remodeling (ECM Remodeling) refers to the dynamic process where the structure and composition of the extracellular matrix (a network of proteins and other molecules outside cells) are continuously broken down and rebuilt. This process is crucial for tissue development, wound healing, and maintaining healthy skin and hair, but it can also contribute to diseases like fibrosis and cancer if dysregulated.

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research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations, June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

research The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair

1 citations, January 2024 in “International journal of molecular sciences”

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

research Matrisomal Components Involved in Regenerative Wound Healing in Axolotl and Acomys: Implications for Biomaterial Development

January 2023 in “Biomaterials Science”

Certain genes are more active during wound healing in axolotl and Acomys, which could help develop materials that improve human wound healing and regeneration.

research An ERK-Dependent Molecular Switch Antagonizes Fibrosis and Promotes Regeneration in Spiny Mice

1 citations, April 2023 in “Science Advances”

High levels of ERK activity are key for tissue regeneration in spiny mice, and activating ERK can potentially redirect scar-forming healing towards regenerative healing in mammals.

research Human Fibroblast-Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through Interactions With Macrophages

March 2024 in “Advanced science”

A new hydrogel made from human cells improves wound healing by working with immune cells to promote repair.

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