Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

    May 2021 in “ Nature Communications ”
    Hans I.Chen Harn, Sheng Wang, Yung-Chih Lai, Ben Van Handel, Ya-Chen Liang, Stephanie B. Tsai, Ina Maria Schiessl, Arijita Sarkar, Haibin Xi, Michael Hughes, S. Kaemmer, Ming Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Ting-Xin Jiang, Cheng-Ming Chuong
    Image of study
    TLDR Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.
    The study explores the role of tissue mechanics and Twist1 in wound-induced hair follicle regeneration in mice and African spiny mice. The study found that tissue stiffness plays a crucial role in hair follicle regeneration, with a softness of less than 15 kPa being necessary for hair neogenesis to occur. Twist1 was identified as a key regulator in activating various processes involved in hair follicle regeneration. The study sheds light on evo-devo advantages and provides perspectives for future implications in developing new therapies for hair loss.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    6 / 1000+ results

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Verteporfin and Microneedling

      in Treatments 8 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Verteporfin day 119 update - donor hair regeneration human trial

      in Research/Science  146 upvotes 2 years ago
      A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  862 upvotes 3 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

    Related Research

    3 / 3 results