Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

May 2021 in “ Nature Communications ”

Hans I.Chen Harn, Sheng Wang, Yung-Chih Lai, Ben Van Handel, Ya-Chen Liang, Stephanie B. Tsai, Ina Maria Schiessl, Arijita Sarkar, Haibin Xi, Michael Hughes, S. Kaemmer, Ming Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Ting-Xin Jiang, Cheng-Ming Chuong

hair follicle regeneration tissue mechanics Twist1 wound-induced hair follicle regeneration tissue stiffness hair neogenesis

TLDR Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.

The study explores the role of tissue mechanics and Twist1 in wound-induced hair follicle regeneration in mice and African spiny mice. The study found that tissue stiffness plays a crucial role in hair follicle regeneration, with a softness of less than 15 kPa being necessary for hair neogenesis to occur. Twist1 was identified as a key regulator in activating various processes involved in hair follicle regeneration. The study sheds light on evo-devo advantages and provides perspectives for future implications in developing new therapies for hair loss.

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research Comparative Regenerative Biology of Spiny (Acomys Cahirinus) and Laboratory (Mus Musculus) Mouse Skin

37 citations , April 2019 in “Experimental Dermatology”

Spiny mice are better at regenerating hair after injury than laboratory mice and could help us understand how to improve human skin repair.

research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

145 citations , November 2018 in “Nature Communications”

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

research Mechanical Forces in Skin Disorders

65 citations , June 2018 in “Journal of Dermatological Science”

Skin problems can be caused or worsened by physical forces and pressure on the skin.

research Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

16 citations , May 2016 in “Journal of Investigative Dermatology”

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

research An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin

173 citations , September 2015 in “Developmental cell”

The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.

research dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration

128 citations , August 2015 in “Cell Stem Cell”

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations , June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , January 2013 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Skin Shedding and Tissue Regeneration in African Spiny Mice (Acomys)

418 citations , September 2012 in “Nature”

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

research Module-Based Complexity Formation: Periodic Patterning in Feathers and Hairs

47 citations , May 2012 in “Wiley Interdisciplinary Reviews-Developmental Biology”

The conclusion is that understanding how feathers and hairs pattern can help in developing hair regeneration treatments.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Distinct Mechanisms Underlie Pattern Formation in the Skin and Skin Appendages

25 citations , January 2006 in “Birth Defects Research”

Different processes create patterns in skin and things like hair and feathers.

research Integument Pattern Formation Involves Genetic and Epigenetic Controls: Feather Arrays Simulated by Digital Hormone Models

112 citations , January 2004 in “The International journal of developmental biology”

Feather patterns form through genetic and epigenetic controls, with cells self-organizing into periodic patterns.

3 / 3 results

research Understanding the Functional Contribution of Dermal Stem Cells to Hair Follicle Regeneration and Skin Wound Healing

January 2017

Dermal stem cells help regenerate hair follicles and heal skin wounds.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , October 2012 in “Seminars in Cell & Developmental Biology”

The conclusion is that certain cell interactions and signals are crucial for hair growth and regeneration.

research The Influence of Flightless I: Regeneration Versus Wound Healing

1 citations , April 2011 in “Journal of Investigative Dermatology”

Blocking RANK signaling might help treat metastatic melanoma, but more research is needed.