Symmetry Breaking of Tissue Mechanics in Wound-Induced Hair Follicle Regeneration of Laboratory and Spiny Mice

    May 2021 in “ Nature Communications ”
    Hans I.Chen Harn, Sheng Wang, Yung-Chih Lai, Ben Van Handel, Ya-Chen Liang, Stephanie B. Tsai, Ina Maria Schiessl, Arijita Sarkar, Haibin Xi, Michael Hughes, S. Kaemmer, Ming Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Ting-Xin Jiang, Cheng-Ming Chuong
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    TLDR Tissue stiffness affects hair follicle regeneration, and Twist1 is a key regulator.
    The study explores the role of tissue mechanics and Twist1 in wound-induced hair follicle regeneration in mice and African spiny mice. The study found that tissue stiffness plays a crucial role in hair follicle regeneration, with a softness of less than 15 kPa being necessary for hair neogenesis to occur. Twist1 was identified as a key regulator in activating various processes involved in hair follicle regeneration. The study sheds light on evo-devo advantages and provides perspectives for future implications in developing new therapies for hair loss.
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