Neutrophil Extracellular Traps Impair Regeneration

    October 2021 in “ Journal of Cellular and Molecular Medicine ”
    Eric M. Wier, Mayumi Asada, Gaofeng Wang, Martin P. Alphonse, Ang Li, Chase Hintelmann, Evan Sweren, Christine Youn, Brittany Pielstick, Roger V. Ortines, Chenyi Lyu, M. Daskam, Lloyd S. Miller, Nathan K. Archer, Luis A. Garza
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    TLDR White blood cells and their traps can slow down the process of new hair growth after a wound.
    The study "Neutrophil extracellular traps impair regeneration" explored the role of neutrophils, a type of white blood cell, in wound-induced hair follicle neogenesis (WIHN), a process of new hair follicle formation after wounding. The researchers found that mature neutrophils and their extracellular traps (NETs) hinder the regeneration process. This was demonstrated by increased WIHN in mice with mature neutrophil depletion or defective NET production. The study also identified a significant increase in mature and activated neutrophils in the wound beds of low regenerating mice lacking TLR3, a receptor that promotes WIHN. These findings suggest that while mature neutrophils are important for preventing infection, their presence and NETs negatively impact regeneration and WIHN.
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