Sonic Hedgehog Signaling in the Regulation of Barrier Tissue Homeostasis and Inflammation

    October 2021 in “ FEBS Journal
    Ching‐In Lau, Diana C. Yánez, Eleftheria Papaioannou … Tessa Crompton
    Studysummary This review examines the role of Sonic Hedgehog signaling in the maintenance and repair of skin and lung barriers, and its influence on inflammation and atopic diseases; it presents no new clinical findings.
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    Research cited in this study 6

    1. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    2. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    3. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    4. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    5. Hedgehog Signaling Is Essential For Normal Wound Healing Wound Repair and Regeneration · 2008
    6. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007