Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice

    June 2022 in “ Frontiers in immunology ”
    Eun-Jin Lee, Mingyu Kim, You Jeong Lee
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    TLDR Increasing Treg cells in the skin does not cure hair loss from alopecia areata in mice.
    The study explored the potential of using expanded regulatory T cells (Tregs) to treat alopecia areata (AA), an autoimmune disease where cytotoxic T lymphocytes attack hair follicles. Using the C3H/HeJ mouse model, researchers found that while Tregs can proliferate in the skin with the help of IL-2 cytokine antibody complex, their expansion was not enough to induce hair growth or suppress the autoreactive CD8 T cells responsible for AA. Consequently, the study concluded that simply increasing Treg numbers in the skin does not reverse established AA, indicating that a more comprehensive immunotherapy approach is necessary for effective treatment.
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