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research Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

278 citations , March 2013 in “Gut”

In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.

research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

This study summarizes how the IL-23/IL-17 axis contributes to inflammatory skin diseases like psoriasis and highlights that biologics targeting this pathway, including monoclonal antibodies against IL-23 and IL-17, have shown efficacy in clinical trials for these conditions.

research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

140 citations , March 2013 in “The journal of immunology/The Journal of immunology”

This study found that IL-7 is crucial for the survival of memory regulatory T cells in the skin of mice, whereas IL-2 is essential for their initial generation but not for their maintenance.

research Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism

68 citations , November 2015 in “The Journal of Allergy and Clinical Immunology”

In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.

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learn Hair Transplant

How is the cost of a hair transplant calculated? The cost of a hair transplant is primarily based on the number of grafts needed.
Is there an age limit for hair transplantation? There is no fixed age limit. Many surgeons are cautious under about 25, because the future pattern of loss is hard to predict.
How much does a hair transplant cost in Turkey? Clinics in Turkey quote about $1,500 to $6,500. Very low prices call for checking who will actually perform the surgery.
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learn Scalp Micropigmentation

How long does a scalp micropigmentation session take? Each scalp micropigmentation session typically takes 2 to 4 hours.

learn Redensyl

Cosmetic ingredient blend sold for thinning hair

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community Today I received my first Batch Follicopeptide

in Treatment 139 upvotes 8 months ago

A user purchased an expensive hair loss treatment called Follicopeptide, which many others in the conversation believe to be a scam, suggesting instead the use of proven treatments like minoxidil and finasteride. Some users report positive effects from Follicopeptide, but skepticism remains high due to lack of transparency about its ingredients and the company's credibility.

community Il PP405 è molto promettente ma non è l'unico in grado di liberarci dalla iattura

3 upvotes 1 year ago

PP405 shows promise in hair loss treatment, but stem cell therapy using adipose-derived stem cells and ATP also successfully reversed androgenetic alopecia in mice. Stem cell therapy is costly, and some doubt the effectiveness of PP405 based on press releases.

community Shed 2 years into finasteride and minoxidil

in Minoxidil 8 upvotes 2 years ago

A user has been on finasteride for 1.5 years and minoxidil for 2 years, experiencing worsening hair shedding, losing 300+ hairs per wash. They are concerned if this indicates the medicine isn't working and are seeking others' experiences.

community Part 2 of previous post including pictures

21 upvotes 1 month ago

The user has been experiencing hair loss despite using finasteride and dutasteride, with recent photos showing significant thinning. They are considering increasing their dutasteride dosage and possibly trying microneedling, while also addressing concerns about diet and nutrient deficiencies.

community I’ve been on Finasteride for 6.5 months. (5 months on 0.2mg and 1.5 months on 0.5mg) Here are the progress pictures.

in Progress Pictures 183 upvotes 1 year ago

A 21-year-old has been using finasteride for 6.5 months, starting with 0.25 mg daily and increasing to 0.5 mg, experiencing improved hair quality and no significant side effects. They have not used minoxidil due to convenience and health reasons, and they noticed progress in hair growth, particularly at the crown, after about 4 months.

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