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research Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice

5 citations , June 2022 in “Frontiers in immunology”

This study observed that expanding regulatory T cells in the skin of mice with alopecia areata did not reverse the condition, indicating that additional immunotherapy may be necessary.

research CD4+ Treg expansion arrests disease progression in a pre-clinical model of alopecia areata

May 2023 in “The Journal of Immunology”

In this study, treatment with IL-2C to expand Tregs effectively halted hair loss progression in a murine model of alopecia areata.

research 039 Expansion of regulatory T Cells restrains pathogenic CD8 T Cells in a murine model of alopecia areata

July 2024 in “Journal of Investigative Dermatology”

Expanding regulatory T cells may help treat alopecia areata by reducing harmful immune cells.

COVID-19 and Sex Differences: Mechanisms and Biomarkers

research COVID-19 and Sex Differences

185 citations , August 2020 in “Mayo Clinic Proceedings”

This review discusses biological sex differences in COVID-19 outcomes and reports no new clinical results; it identifies a need for studies to clarify how sex influences disease progression.

Possible Immunomodulating Effect of Retinol on Cytokine Secretion in Patients with Recurrent Furunculosis

research Possible Immunomodulating Effect of Retinol on Cytokines Secretion in Patients with Recurrent Furunculosis

4 citations , July 2017 in “Archivum Immunologiae et Therapiae Experimentalis”

This study observed that patients with recurrent furunculosis had different cytokine profiles compared to healthy subjects and that retinol stimulation altered cytokine secretion in both groups.

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community Dental Cavitations, Inflammatory Cytokines (RANTES/CCL5) and Hair Loss

2 months ago

Dental cavitations and their potential link to hair loss through systemic inflammation. The user experienced hair regrowth after dental surgery, suggesting a connection between oral health and hair loss, but this theory is not widely accepted or proven.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 2 years ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

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learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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