Frontiers in Alopecia Areata Pathobiology Research

    Amos Gilhar, Rimma Laufer-Britva, Aviad Keren, Ralf Paus
    Studysummary This review discusses emerging research areas in alopecia areata pathobiology, highlighting the potential roles of unconventional immune cells and the need for more targeted therapeutic strategies, but reports no new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 49

    1. Apremilast and Tofacitinib Exert Differential Effects in the Humanized Mouse Model of Alopecia Areata British Journal of Dermatology · 2019
    2. Possible Role of ILC1 in the Pathogenesis of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    3. Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity British journal of dermatology/British journal of dermatology, Supplement · 2019
    4. New Drugs Under Investigation for the Treatment of Alopecias Expert Opinion on Investigational Drugs · 2019
    5. Tofacitinib Therapy for Children with Severe Alopecia Areata Journal of the American Academy of Dermatology · 2019
    6. JAK Inhibitors and Alopecia Areata Lancet · 2019
    7. Alopecia Areata in Severe Atopic Dermatitis Treated With Dupilumab Journal of Investigational Allergology and Clinical Immunology · 2018
    8. A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata Archives of dermatological research · 2018
    9. Response to Ustekinumab in Three Pediatric Patients with Alopecia Areata Pediatric dermatology · 2018
    10. High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata JCI insight · 2018
    11. Rethinking The Classification Of Alopecia Areata Journal of the American Academy of Dermatology · 2018
    12. Ruxolitinib for the Treatment of Severe Alopecia Areata Journal of the American Academy of Dermatology · 2018
    13. JAK Inhibitors for Treatment of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    14. Comorbidities in Alopecia Areata: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2018
    15. An Integrated Model of Alopecia Areata Biomarkers Highlights Both TH1 and TH2 Upregulation Journal of Allergy and Clinical Immunology · 2018
    16. Alopecia Areata and the Gut: The Link Opens Up for Novel Therapeutic Interventions Expert Opinion on Therapeutic Targets · 2018
    17. iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata Journal of autoimmunity · 2018
    18. Alopecia Areata After Dupilumab for Atopic Dermatitis JAAD case reports · 2018
    19. Novel Therapies for Alopecia Areata: The Era of Rational Drug Development The Journal of Allergy and Clinical Immunology · 2017
    20. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    21. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    22. SOCS3 Treatment Prevents the Development of Alopecia Areata by Inhibiting CD8+ T Cell-Mediated Autoimmune Destruction Oncotarget · 2017
    23. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    24. Successful Hair Regrowth in an Acute Diffuse Form of Alopecia Areata During Oral Tacrolimus Treatment in a Patient With Rheumatoid Arthritis Journal of the European Academy of Dermatology and Venereology · 2016
    25. Genomewide Analysis of Copy Number Variants in Alopecia Areata in a Central European Cohort Reveals Association with MCHR2 Experimental Dermatology · 2016
    26. ULBP3: A Marker for Alopecia Areata Incognita Archives of Dermatological Research · 2016
    27. Gamma Delta T Cells as Novel Players in Alopecia Areata Pathobiology: Vdelta1 Positive T Lymphocytes May Recognize Stressed Hair Follicle Keratinocytes, Leading to IFN Gamma-Dependent Hair Follicle Dystrophy and Immune Privilege Collapse Journal of Investigative Dermatology · 2016
    28. Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse British journal of dermatology/British journal of dermatology, Supplement · 2016
    29. Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies Autoimmunity reviews · 2016
    30. Laser Capture Microdissection Reveals Transcriptional Abnormalities In Alopecia Areata Before, During, And After Active Hair Loss Journal of Investigative Dermatology · 2015
    31. Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment Experimental dermatology · 2015
    32. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    33. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    34. Diagnostic Usefulness of a Peribulbar Eosinophilic Infiltrate in Alopecia Areata JAMA Dermatology · 2014
    35. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    36. Mechanisms Regulating Skin Immunity and Inflammation Nature Reviews Immunology · 2014
    37. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    38. Birth, Life, and Death of the MAGE3 Hypothesis of Alopecia Areata Pathobiology Journal of Dermatological Science · 2013
    39. Blocking Potassium Channels (Kv1.3): A New Treatment Option for Alopecia Areata? Journal of Investigative Dermatology · 2013
    40. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
    41. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    42. Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege? Investigative Ophthalmology & Visual Science · 2011
    43. Trichohyalin Is a Potential Major Autoantigen in Human Alopecia Areata Journal of Proteome Research · 2010
    44. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    45. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    46. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    47. Failure to Induce Alopecia Areata in C3H/HeJ Mice with Exogenous Interferon Gamma Journal of experimental animal science · 2006
    48. Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata Journal of Investigative Dermatology · 2002
    49. Hair Growth Inhibition by Heparin in Mice: A Model System for Studying the Modulation of Epithelial Cell Growth by Glycosaminoglycans British Journal of Dermatology · 1991

    Related research 6

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023
    2. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    3. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    4. Current Status of Treatments for Alopecia Areata 2014
    5. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    6. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005