A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata

    November 2018 in “ Archives of dermatological research ”
    Daniela Mikhaylov, Ana B. Pavel, Christopher J. Yao … Emma Guttman‐Yassky
    Studysummary Apremilast was not effective in treating moderate-to-severe alopecia areata.
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    Research cited in this study 25

    1. An Investigation of Vitamin D Status in Alopecia Areata Clinical and Experimental Medicine · 2018
    2. Lack of Efficacy of Apremilast in 9 Patients with Severe Alopecia Areata Journal of the American Academy of Dermatology · 2017
    3. The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm Advances in Therapy · 2017
    4. The Changing Landscape of Alopecia Areata: The Translational Landscape Advances in Therapy · 2017
    5. Topical Janus Kinase Inhibitors for the Treatment of Pediatric Alopecia Areata Journal of the American Academy of Dermatology · 2017
    6. Reversal of Alopecia Universalis by Tofacitinib: A Case Report Annals of Internal Medicine · 2016
    7. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    8. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    9. A Novel Therapeutic Paradigm for Patients with Extensive Alopecia Areata Expert Opinion on Biological Therapy · 2016
    10. Extensive Alopecia Areata Is Reversed by IL-12/IL-23p40 Cytokine Antagonism The Journal of Allergy and Clinical Immunology · 2015
    11. Current Treatments for Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2015
    12. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    13. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    14. The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo Journal of Dermatological Science · 2014
    15. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    16. Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients Journal of the American Academy of Dermatology · 2014
    17. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    18. The Effect of Oral Cyclosporine in the Treatment of Severe Alopecia Areata Cutaneous and ocular toxicology · 2013
    19. Combination Therapy with Cyclosporine and Psoralen Plus Ultraviolet A in Patients with Severe Alopecia Areata: A Retrospective Study with a Self-Controlled Design Annals of dermatology/Annals of Dermatology · 2013
    20. Systemic Treatment for Alopecia Areata Dermatologic therapy · 2011
    21. Alopecia Areata Update Journal of the American Academy of Dermatology · 2010
    22. Interventions for Alopecia Areata Cochrane library · 2008
    23. A Comparison of the Efficacy, Relapse Rate, and Side Effects Among Three Modalities of Systemic Corticosteroid Therapy for Alopecia Areata Dermatology · 2006
    24. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005
    25. Guidelines for the Management of Alopecia Areata British Journal of Dermatology · 2003

    Related research 4

    1. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    2. Linear Alopecia Areata JAAD case reports · 2018
    3. Treating Resistant Cases of Alopecia Universalis Journal of cosmetology & trichology · 2018
    4. Overview of Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013