The Changing Landscape of Alopecia Areata: The Translational Landscape

    June 2017 in “ Advances in Therapy ”
    Etienne C.E. Wang, Angela M. Christiano
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    TLDR New treatments for hair loss are showing promise due to better understanding of genetics and the immune system.
    The 2017 review outlined advancements in the understanding and treatment of Alopecia Areata (AA), emphasizing the role of genetic studies in identifying key genes and pathways, such as the JAK-STAT signaling pathway, which led to the use of JAK inhibitors with promising results. It also discussed the potential of other treatments like abatacept, simvastatin/ezetimibe, and biologic therapies targeting IL-15, IFN-y, and IL-2, with low-dose IL-2 showing modest results. The review highlighted the use of non-invasive diagnostic tools and the ALADIN index for disease activity assessment. It concluded that ongoing research and a deeper understanding of the immune system are paving the way for more precise and personalized treatments for AA, though larger studies are needed to confirm the efficacy of some of these treatments. The work was supported by NIH Grant P50 AR070588-01, and no new data were generated or analyzed for this review.
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      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

      community any news about DUPA (Diffuse unpatterned alopecia)?

      in Research/Science  11 upvotes 1 year ago
      The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       8 upvotes 8 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

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