Lack of Efficacy of Apremilast in 9 Patients with Severe Alopecia Areata

A study involving 9 patients with severe alopecia areata (AA) tested the efficacy of apremilast, a phosphodiesterase 4 inhibitor known to suppress IFN-γ production. Despite the theoretical basis for its use, the study concluded that apremilast was not effective in treating AA. This finding was significant as it contrasted with the successful use of Janus kinase (JAK) inhibitors, which target similar pathways and have shown positive results in treating AA.