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Did you mean Phosphodiesterase 4 inhibitors?

GlossaryPDE4 inhibitors (Phosphodiesterase 4 inhibitors)

block an enzyme to reduce inflammation and immune responses

PDE4 inhibitors, also known as Phosphodiesterase 4 inhibitors or PDE4i, are a class of drugs that block the enzyme phosphodiesterase 4. This enzyme is involved in breaking down cyclic adenosine monophosphate (cAMP), a molecule that plays a crucial role in regulating inflammation and immune responses. By inhibiting PDE4, these drugs can help reduce inflammation and are used to treat conditions like psoriasis, chronic obstructive pulmonary disease (COPD), and certain types of alopecia.

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the stimulant you know and love can be used topically to stimulate hair

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Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

research Systematic Review of Newer Agents for the Management of Alopecia Areata in Adults: Janus Kinase Inhibitors, Biologics and Phosphodiesterase-4 Inhibitors

12 citations, December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

New oral treatments for adult hair loss show promise, especially JAK inhibitors, with mild side effects.

research Alopecia Areata: Treatment Options and Efficacy

182 citations, December 2017 in “Journal of the American Academy of Dermatology”

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

research Lack of Efficacy of Apremilast in 9 Patients with Severe Alopecia Areata

23 citations, September 2017 in “Journal of the American Academy of Dermatology”

Apremilast did not work for treating severe alopecia areata.

$Apremilast Is Efficacious in Refractory Alopecia Areata$

research Apremilast Is Efficacious in Refractory Alopecia Areata

9 citations, May 2019 in “Journal of dermatological treatment”

Apremilast helps regrow hair in hard-to-treat alopecia areata.

research Non-FDA-Approved Uses of Apremilast in Dermatology: A Review of Current Available Literature

1 citations, September 2022 in “Nepal journal of dermatology, venereology & leprology”

Apremilast shows promise for several skin conditions but needs more research.

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