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    Did you mean Phosphodiesterase Inhibitors?
    Glossary Phosphodiesterase Inhibitors

    block enzymes that break down cyclic nucleotides

    Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

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    Research 30 of 551

    1. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    2. Efficacy of the phosphodiesterase-4 inhibitor, apremilast, in a patient with severe alopecia areata European Journal of Dermatology · 2019 · 10 citations
    3. PD59-09 PHOSPHODIESTERASE INHIBITORS COULD REVERSE THE PROLIFERATION OF BPH EPITHELIAL CELLS INDUCED BY CD8+ T CELLS IN LOW ANDROGEN CONDITION The Journal of Urology · 2018
    4. Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions Springer eBooks · 2018
    5. The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms Journal of Dermatological Science · 2018 · 21 citations
    6. The effects of phosphodiesterase 3 (PDE3) inhibitor on hair follicle cell viability and hair growth Seoul National University Open Repository (Seoul National University) · 2020 · 1 citations
    7. Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review Dermatologic Therapy · 2020 · 9 citations
    8. The use of phosphodiesterase inhibitors for the treatment of alopecia Journal of Dermatological Treatment · 2019 · 3 citations
    9. Comment on ‘Androgenetic alopecia is associated with increased scalp hardness’: role of phosphodiesterase inhibitors? Journal of The European Academy of Dermatology and Venereology · 2020 · 1 citations
    10. 467 Novel selective phosphodiesterase inhibitors promote the adipogenic function of dermal fibroblasts: Implication to treat hair loss Journal of Investigative Dermatology · 2021
    11. Phosphodiesterase inhibitors used in androgenic alopecia as a possible risk factor for testicular tumor Medicina Clínica (english Edition) · 2023
    12. 570 Targeting phosphodiesterase 8A (PDE8A) to boost adipogenesis and hair regeneration Journal of Investigative Dermatology · 2024
    13. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    14. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) The Aging Male · 2026
    15. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) Figshare · 2026
    16. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) Figshare · 2026
    17. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016 · 15 citations
    18. FDA approves label addition for PDE-5 inhibitor Urology Times eNews · 2013
    19. Alopecia areata Journal of the American Academy of Dermatology · 2017 · 182 citations
    20. Lack of efficacy of apremilast in 9 patients with severe alopecia areata Journal of the American Academy of Dermatology · 2017 · 23 citations
    21. Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation Theranostics · 2021 · 18 citations
    22. Apremilast is efficacious in refractory alopecia areata Journal of dermatological treatment · 2019 · 9 citations
    23. Non-FDA-Approved Uses of Apremilast in Dermatology: A Review of Current Available literature Nepal journal of dermatology, venereology & leprology · 2022 · 1 citations
    24. Alopecia areata: from pathophysiology to therapeutic innovation Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
    25. 1113 Targeting anti-inflammatory immunonanocarriers to human and murine neutrophils via Ly6 antigen for psoriasiform dermatitis alleviation Journal of Investigative Dermatology · 2023
    26. Alopesi Tedavisinde Kullanılan İlaç Tedavileri ve Yeni Yaklaşımlar 2025
    27. 22-Year-Old Male with Several Discrete Patches of Hair Loss Clinical Cases in Dermatology · 2022
    28. The pharmacological treatment of alopecia areata University of Debrecen Electronic Archive (University of Debrecen) · 2023
    29. Adverse effects of common medications on male fertility Nature Reviews Urology · 2015 · 77 citations
    30. Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia Frontiers in Pharmacology · 2020 · 35 citations