Comment on ‘Androgenetic Alopecia Is Associated with Increased Scalp Hardness’: Role of Phosphodiesterase Inhibitors?

This document is a letter to the editor commenting on a study that hypothesized a link between androgenetic alopecia (AGA) and increased scalp hardness. The authors of the letter suggest that drugs that attenuate or ameliorate TGF-B1 signaling, such as phosphodiesterase inhibitors (PDEI), may represent a future hope for hair disorders like AGA. They cite previous studies that have shown the potential of PDEI drugs like sildenafil, cilostazol, and apremilast to promote hair growth and reduce fibrosis. The authors suggest that further research is needed to determine the ideal dosage and frequency of these drugs, as well as their potential side effects.