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Did you mean TGF-beta signaling?

Glossary TGF-beta signaling

cellular communication process regulating growth, differentiation, and immune responses

TGF-beta signaling, or Transforming Growth Factor-beta signaling, is a cellular communication process that regulates various biological functions, including cell growth, differentiation, and immune responses. This pathway involves the binding of TGF-beta proteins to specific receptors on the cell surface, which then activate intracellular molecules called SMADs to transmit signals to the nucleus, influencing gene expression. This pathway is crucial in maintaining tissue homeostasis and has implications in conditions like cancer, fibrosis, and alopecia.

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Research

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research An investigation of crosstalk between Wnt/β-catenin and transforming growth factor-β signaling in androgenetic alopecia

18 citations , July 2016 in “Medicine”

This study suggests that crosstalk between Wnt/β-catenin and TGF-β signaling pathways may contribute to the development of androgenetic alopecia.

research Comment on ‘Androgenetic alopecia is associated with increased scalp hardness’: role of phosphodiesterase inhibitors?

1 citations , April 2020 in “Journal of The European Academy of Dermatology and Venereology”

This letter to the editor comments on the association between androgenetic alopecia and increased scalp hardness, exploring the possible role of phosphodiesterase inhibitors but provides no new clinical results.

research Molecular biology of hair morphogenesis: Development and cycling

155 citations , August 2003 in “Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution”

This review discusses the conserved molecular mechanisms controlling hair follicle development and cycling and suggests they may also apply to other ectodermal derivatives, like teeth and feathers, but it reports no new results.

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations , January 2018 in “Acta dermato-venereologica”

In this study, researchers identified gremilin-2 as a highly specific gene to the dermal sheath cup, suggesting it plays a key role in maintaining its properties.

research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus

October 2021 in “Research Square (Research Square)”

This study found that gene expression patterns can effectively distinguish the cashmere growth cycle stages and highlight molecular pathways, suggesting melatonin's role in regulating cashmere growth in Inner Mongolian goats.

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Community Join

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community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

59 upvotes 6 months ago

Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

community Hi-c5 protein, explains why the mechanical tension theory may be correct.

22 upvotes 1 month ago

Hair loss may be influenced by mechanical tension and inflammation, with the hi-c5 protein amplifying androgen effects, leading to follicle miniaturization. Treatments like finasteride, minoxidil, and scalp massages are suggested to manage hair loss.

community Microneedling-induced shedding after 5 months?

in Progress Pictures 22 upvotes 10 months ago

A user experienced significant hair loss after starting microneedling, despite using dutasteride and topical minoxidil. They are advised to consult a doctor as the shedding pattern is unusual and may indicate alopecia areata or other scalp conditions.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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