TLDR Nuclear Factor I-C is important for controlling hair growth by affecting the TGF-β1 pathway.
The document reports that Nuclear Factor I-C (NFI-C) is essential for regulating the hair follicle cycle, particularly by modulating the TGF-β1 pathway during the telogen phase of hair growth. Mice lacking NFI-C showed a delayed transition from the telogen to anagen phase, associated with reduced expression of genes like Shh, Wnt5a, and Lef1, which are crucial for hair follicle growth initiation. These NFI-C-null mice also had increased levels of TGF-β1 and the cell cycle inhibitor p21, along with reduced Ki67 expression, indicating impaired progenitor cell activation. The findings suggest that NFI-C represses TGF-β1 signaling, which is necessary for timely hair follicle regeneration. The study's strength cannot be assessed as the number of mice used was not mentioned.
277 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
142 citations,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.
211 citations,
October 2001 in “The FASEB Journal” Noggin is necessary to start the hair growth phase in skin after birth.
73 citations,
November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
231 citations,
October 1999 in “Journal of Clinical Investigation” Activating the Sonic hedgehog gene in mice can start the hair growth phase.
1113 citations,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
19 citations,
November 1971 in “Clinica Chimica Acta” The document concludes that measuring γ-glutamyl transpeptidase activity is more accurate with a higher substrate concentration and using diluted acetic acid to stop the reaction.
21 citations,
May 2022 in “Frontiers in Cell and Developmental Biology” Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
236 citations,
July 2001 in “Trends in Molecular Medicine” Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.
