Overview of Lichen Planopilaris: Diagnosis and Treatment

    July 2018 in “ Elsevier eBooks ”
    Nisha S. Desai, Paradi Mirmirani
    Image of study
    TLDR Lichen Planopilaris is a hair loss condition best treated early with various medications, including hydroxychloroquine, to prevent permanent baldness.
    The document from 2019 provides an overview of Lichen Planopilaris (LPP), a scarring alopecia with autoimmune etiology, affecting mainly Caucasian middle-aged females. It is associated with certain HLA alleles, hypothyroidism, and polycystic ovarian syndrome, with pathogenesis linked to sebaceous gland dysfunction and a defect in PPAR-y protein. Diagnosis is made through dermoscopy and histopathology, showing characteristic features like perifollicular erythema. Treatment options include topical corticosteroids, calcineurin inhibitors, and systemic therapies such as tetracycline antibiotics, with doxycycline and minocycline having a 57% response rate. Hydroxychloroquine is the gold-standard systemic treatment with a 53-83% response rate. Other treatments like thiazolidinediones, oral retinoids, and mycophenolate mofetil (with an 83% effectiveness in a 16-patient series) are considered, while cyclosporine A and oral prednisone are reserved for short-term use. Early diagnosis and potentially combined treatments are crucial for preventing permanent hair loss.
    Discuss this study in the Community →

    Research cited in this study

    23 / 23 results

    Related Community Posts Join

    6 / 41 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community I think I’ve finally found the reason for my hair loss

      in Chat  98 upvotes 2 weeks ago
      The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

      community C’est terrible - at my wits end

      in Female  449 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community He used Dutasteride for 20 years. Interview

      in Treatment  109 upvotes 1 month ago
      Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

    Related Research

    8 / 8 results