A Case Series of 46 Patients With Lichen Planopilaris: Demographics, Clinical Evaluation, and Treatment Experience

    June 2014 in “ Journal of Dermatological Treatment ”
    Anna Lyakhovitsky, Boaz Amichai, Christina Sizopoulou, Aviv Barzilai
    Image of study
    TLDR Most treatments for lichen planopilaris were found to be generally unsatisfactory.
    In a retrospective review of 46 patients with lichen planopilaris (LPP), 82.6% were women and 17.4% were men. The study found no clear link between medical history or medications and LPP onset. Itching scalp was the most common symptom (54.34%), and 39.1% of patients had scalp-wide involvement. Intralesional corticosteroid injections were the most effective for symptom relief, and the combination of hydroxychloroquine and topical corticosteroids had the highest remission rate, with 33% achieving remission after 18 months. However, 50% of those in remission needed ongoing treatment, and no patients saw visible hair regrowth. The study concluded that the treatments used were generally unsatisfactory for LPP. After starting treatment, 6.5% of patients achieved remission at 3 months, 13% had partial stabilization, and 80.4% had active disease. Remission rates improved over time, reaching 33.3% at 1.5 years, but no patients experienced more than 50% scalp hair loss.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 41 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Anger and frustration as I finally learn my diagnosis.

      in Female  6 upvotes 1 year ago
      A young female diagnosed with Lichen planopilaris (LPP) experienced years of misdiagnosis and ineffective treatments, including a hair transplant and other procedures. She is considering litigation due to the misdiagnosis and has learned that LPP is chronic, hair loss can be stopped with ongoing medication, but lost hair cannot regrow.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community 5mg oral minoxidil + 100mg Spironolactone

      in Progress Pictures  9 upvotes 1 year ago
      A user shared progress pictures using 5mg oral minoxidil and 100mg spironolactone, noting increased body hair and faster nail growth. Another user humorously suggested a new sub for people with similar experiences.

    Related Research

    6 / 6 results