Diagnosis and Management of Primary Cicatricial Alopecia: Part I

January 2008 in “ SKINmed/Skinmed ”

Nina Otberg, Wenyu Wu, Kevin J. McElwee, Jerry Shapiro

primary cicatricial alopecia lymphocytic cicatricial alopecia chronic cutaneous lupus erythematosus discoid lupus erythematosus lichen planopilaris pseudopelade of Brocq central centrifugal cicatricial alopecia alopecia mucinosa keratosis follicularis spinulosa decalvans scarring alopecia DLE CCCA

TLDR The article explains how to diagnose and manage certain types of scarring hair loss.

In the first part of this 2-part article, the authors reviewed primary cicatricial alopecias, focusing on those that are predominantly lymphocytic. They discussed the classification, epidemiology, diagnostic approach, and patient management of various lymphocytic cicatricial alopecias, including chronic cutaneous lupus erythematosus (discoid lupus erythematosus), lichen planopilaris, classic pseudopelade of Brocq, central centrifugal cicatricial alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. The article aimed to provide a comprehensive understanding of these conditions to aid in their diagnosis and management. Part II was intended to cover neutrophilic and mixed cicatricial alopecias.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

12 / 12 results

research Histopathologic Evaluation of Alopecias

90 citations , June 2006 in “The American Journal of Dermatopathology”

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

research Acneiform Follicular Mucinosis

19 citations , July 2004 in “Clinical and experimental dermatology”

Acneiform follicular mucinosis can be controlled with systemic corticosteroids.

research Medical and Surgical Therapies for Alopecias in Black Women

105 citations , April 2004 in “Dermatologic Therapy”

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.

research Primary Cicatricial Alopecias: Clinicopathology of 112 Cases

254 citations , December 2003 in “Journal of the American Academy of Dermatology”

Accurate diagnosis and aggressive treatment are crucial to prevent permanent hair loss in cicatricial alopecia.

research Alopecia Mucinosa: Report of a Case and Review

21 citations , April 2003 in “Journal of cutaneous medicine and surgery”

Alopecia mucinosa can be treated successfully with minocycline in some cases.

research Lymphocytic Mediated Alopecia: Histological Classification by Pattern Analysis

29 citations , March 2001 in “Clinics in Dermatology”

Steven Kossard classified lymphocyte-related hair loss into four patterns, each linked to different types of baldness.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations , August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Elastic Tissue in Scars and Alopecia

80 citations , March 2000 in “Journal of cutaneous pathology”

The VVG stain effectively differentiates scar tissue from normal skin and helps classify types of permanent alopecia.

research Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias

57 citations , August 1999 in “Archives of dermatology”

Hair follicles grow hair and release it through the skin.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

research Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans

78 citations , April 1994 in “Archives of dermatology”

The study found that Keratosis Pilaris Atrophicans is a genetic skin condition that starts in childhood, involves inflammation and scarring, and current treatments are only somewhat effective.

research Alopecia

22 citations , June 1980 in “International Journal of Dermatology”

The document concludes that correct diagnosis of alopecia types is crucial, scalp biopsies are important, and more research is needed.

Related Community Posts Join

6 / 414 results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community You will lose hair if your prostaglandins aren't in balance

in Research/Science 58 upvotes 7 months ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

community Losing Hair on Dutasteride? You might have LPP

in Research/Science 96 upvotes 7 months ago

Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Can we get a reality check on PP405?

in Research/Science 79 upvotes 1 week ago

PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

community Pelage, PP405, is creating a database for potential new trial volunteers

in Research/Science 149 upvotes 2 weeks ago

PP405 is a new hair loss treatment targeting dormant hair follicles, with ongoing trials. Some users consider stopping finasteride and minoxidil to join trials, while others doubt its effectiveness.

Related Research

1 / 1 results

research Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus

46 citations , June 2018 in “American Journal of Clinical Dermatology”

Hair loss is common in lupus patients and can be permanent or reversible, depending on the type, with various treatments available.