Diagnosis and Management of Primary Cicatricial Alopecia: Part I

January 2008 in “ SKINmed/Skinmed ”

Nina Otberg, Wenyu Wu, Kevin J. McElwee, Jerry Shapiro

primary cicatricial alopecia lymphocytic cicatricial alopecia chronic cutaneous lupus erythematosus discoid lupus erythematosus lichen planopilaris pseudopelade of Brocq central centrifugal cicatricial alopecia alopecia mucinosa keratosis follicularis spinulosa decalvans scarring alopecia DLE CCCA

TLDR The article explains how to diagnose and manage certain types of scarring hair loss.

In the first part of this 2-part article, the authors reviewed primary cicatricial alopecias, focusing on those that are predominantly lymphocytic. They discussed the classification, epidemiology, diagnostic approach, and patient management of various lymphocytic cicatricial alopecias, including chronic cutaneous lupus erythematosus (discoid lupus erythematosus), lichen planopilaris, classic pseudopelade of Brocq, central centrifugal cicatricial alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. The article aimed to provide a comprehensive understanding of these conditions to aid in their diagnosis and management. Part II was intended to cover neutrophilic and mixed cicatricial alopecias.

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Research cited in this study

12 / 12 results

research Histopathologic Evaluation of Alopecias

90 citations, June 2006 in “The American Journal of Dermatopathology”

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

research Acneiform Follicular Mucinosis

19 citations, July 2004 in “Clinical and experimental dermatology”

Acneiform follicular mucinosis can be controlled with systemic corticosteroids.

research Medical and Surgical Therapies for Alopecias in Black Women

105 citations, April 2004 in “Dermatologic Therapy”

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.

research Primary Cicatricial Alopecias: Clinicopathology of 112 Cases

254 citations, December 2003 in “Journal of the American Academy of Dermatology”

Accurate diagnosis and aggressive treatment are crucial to prevent permanent hair loss in cicatricial alopecia.

research Alopecia Mucinosa: Report of a Case and Review

21 citations, April 2003 in “Journal of cutaneous medicine and surgery”

Alopecia mucinosa can be treated successfully with minocycline in some cases.

research Lymphocytic Mediated Alopecia: Histological Classification by Pattern Analysis

29 citations, March 2001 in “Clinics in Dermatology”

Steven Kossard classified lymphocyte-related hair loss into four patterns, each linked to different types of baldness.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations, August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research Elastic Tissue in Scars and Alopecia

80 citations, March 2000 in “Journal of cutaneous pathology”

The VVG stain effectively differentiates scar tissue from normal skin and helps classify types of permanent alopecia.

research Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias

57 citations, August 1999 in “Archives of dermatology”

Hair follicles grow hair and release it through the skin.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations, January 1997 in “Journal of the American Academy of Dermatology”

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

research Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans

78 citations, April 1994 in “Archives of dermatology”

The study found that Keratosis Pilaris Atrophicans is a genetic skin condition that starts in childhood, involves inflammation and scarring, and current treatments are only somewhat effective.

research Alopecia

22 citations, June 1980 in “International Journal of Dermatology”

The document concludes that correct diagnosis of alopecia types is crucial, scalp biopsies are important, and more research is needed.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

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community Primary Care Provider told me to not be concerned and just take biotin.

in Finasteride/Dutasteride 2 upvotes 1 month ago

A 19-year-old was advised by their primary care provider to take biotin for hair loss instead of minoxidil or finasteride due to potential side effects and age concerns. The user is considering seeking a second opinion from a dermatologist.

community If DHT is the one big primary reason for Hairloss.. Then other reasons are hoax?

in Chat 8 upvotes 2 years ago

The conversation discusses various theories and suggestions for hair loss, with a focus on DHT as the primary cause. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community We need to keep these snake oil companies accountable.

in Treatment 121 upvotes 5 months ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

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research Hair and Scalp Changes in Cutaneous and Systemic Lupus Erythematosus

46 citations, June 2018 in “American Journal of Clinical Dermatology”

Hair loss is common in lupus patients and can be permanent or reversible, depending on the type, with various treatments available.