Hair Follicle Biology, the Sebaceous Gland, and Scarring Alopecias

    August 1999 in “ Archives of dermatology
    Kurt S. Stenn, John P. Sundberg, Leonard C. Sperling
    TLDR Hair follicles grow hair and release it through the skin.
    The document discussed the complex functions of the hair follicle, emphasizing its ability to produce the multicellular hair shaft while maintaining an "epithelial finger" in the deep dermis. It described the process by which the hair shaft, along with the inner root sheath, moves outward as a unit, facilitated by a slippage plane in the outer root sheath. The hair shaft is eventually separated from the sheath below the sebaceous duct and exits the pilary canal as a sheath-free hair fiber.
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      in Research  830 upvotes 8 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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