Lichen Planopilaris: Update on Diagnosis and Treatment

    March 2009 in “ Seminars in Cutaneous Medicine and Surgery ”
    P. Assouly, P. Reygagne
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    TLDR New insights show Lichen Planopilaris is a rare, scarring hair loss condition, hard to treat, mainly affecting middle-aged women, and significantly impacts mental health.
    In 2009, an update on Lichen Planopilaris (LPP) was provided, detailing the condition as a rare inflammatory disorder causing primary cicatricial alopecia, with a higher incidence in women aged 40 to 60. LPP is characterized by specific skin and hair changes and can be divided into three variants. Diagnosis relies on clinical examination and histopathology, particularly in early stages, and differentiating LPP from other conditions is crucial. Treatment is challenging, often leading to relapses, and hair regrowth is generally not possible due to the scarring nature of the condition. The document highlights the psychological impact on patients and the necessity for further research and controlled treatment trials.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Research/Science  98 upvotes 3 weeks ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 1 week ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  82 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community Scalp is constantly uncomfortable and irritated with lots of hair loss

      in Chat  7 upvotes 1 year ago
      The individual has experienced a sore, stiff, and itchy scalp with hair loss for 4.5 years, and has noticed increased thinning and miniaturized hairs, especially at the temples. They have tried ketoconazole shampoo without success and are considering finasteride for treatment.

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