An Open-Label Pilot Clinical Trial of the JAK Inhibitor Tofacitinib for Alopecia Areata

    April 2016 in “ Journal of Investigative Dermatology ”
    Ali Jabbari, Jane Cerise, J.C. Chen, Grace Ulerio, J. Borbon, Sreetha Sidharthan, Raphael Clynes, Angela M. Christiano, Julian Mackay‐Wiggan
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    TLDR Tofacitinib, a JAK inhibitor, improved hair regrowth in most patients with severe alopecia areata and had minimal side effects.
    In a 2016 open-label pilot clinical trial by Columbia University, 12 patients with moderate to severe alopecia areata were treated with the JAK inhibitor tofacitinib. Eleven patients completed the trial, and after increasing the dose from 5mg to 10mg twice daily, 8 patients experienced at least 50% improvement in their condition. The study also correlated skin gene expression profiles and the Alopecia Areata Disease Activity Index with clinical responses, supporting previous findings with ruxolitinib, another JAK inhibitor. The trial reported minimal adverse events and suggested that JAK inhibitors could be promising for larger clinical trials in alopecia areata treatment.
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      community What else is good. Besides the big 3.

      in Chat  35 upvotes 1 year ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      by MagicBold in Research  865 upvotes 1 year ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       8 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

      community Xeljanz....the magic drug!!!

       2 upvotes 7 years ago
      A user experienced significant hair regrowth from Xeljanz after severe alopecia but can no longer afford it. They are seeking ways to obtain the medication despite its high cost and potential side effects.

      community can someone help me identify these pls

      in Treatment 4 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

      community DUPA, Non Responders and Connective Tissue Disorders

      in Research/Science  9 upvotes 9 months ago
      A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

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