Tofacitinib Treatment in Patients With Active COVID-19 Infection

September 2021 in “ Curēus ”

Abdulmajeed Alajlan, Lama Alzamil, Amal M Aseri

tofacitinib JAK1 inhibitor JAK3 inhibitor alopecia areata autoimmune disorder hair regrowth alopecia universalis immunosuppression

TLDR Tofacitinib may be safe for COVID-19 patients with alopecia without worsening symptoms, based on two cases.

The document discusses the use of tofacitinib, a JAK1 and JAK3 inhibitor, in treating alopecia areata, an autoimmune disorder causing hair loss. Tofacitinib has been shown to be effective in promoting hair regrowth in patients with this condition. Despite concerns about potential immunosuppression during active COVID-19 infections, the document reports on two cases where patients with alopecia universalis continued their tofacitinib treatment without experiencing any worsening of their COVID-19 symptoms. This suggests that tofacitinib may be safely used without adverse effects on the course of COVID-19, although the sample size is very small with only two cases.

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Research cited in this study

1 / 1 results

research Benefit and Risk Profile of Tofacitinib for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis

54 citations, September 2019 in “Journal of the European Academy of Dermatology and Venereology”

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research Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib

4 citations, July 2018 in “PubMed”

Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.