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GlossaryJAK inhibitor

blocks enzymes involved in immune response and inflammation

A JAK inhibitor, also known as a Janus kinase inhibitor or JAKi, is a type of medication that blocks the activity of Janus kinase enzymes. These enzymes play a crucial role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata

research Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata

9 citations, January 2023 in “Dermatology and therapy”

A 14-year-old girl with severe hair loss regrew her hair using upadacitinib.

The Development of Oral Hairy Leukoplakia During JAK Inhibitor Baricitinib Therapy

research The Development of Oral Hairy Leukoplakia During JAK Inhibitor Baricitinib Therapy

September 2023 in “JAAD case reports”

A man developed oral hairy leukoplakia while on baricitinib, a medication for alopecia and arthritis, and doctors should watch for such side effects.

JAK Inhibitor Baricitinib in the Treatment of Oral Lichen Planus: A Case Report

research JAK Inhibitor Baricitinib in the Treatment of Oral Lichen Planus: A Case Report

January 2024

Baricitinib may effectively treat oral lichen planus.

Small Molecule Inhibitors and Inflammatory Skin Diseases

research Small Molecule Inhibitors and Inflammatory Skin Diseases

March 2018 in “Suez Canal University Medical Journal”

New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

research Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata

42 citations, April 2021 in “JCI insight”

Blocking JAK3 signaling can reverse hair loss from alopecia areata.

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