Emerging Topical and Systemic JAK Inhibitors in Dermatology

    December 2019 in “ Frontiers in Immunology ”
    Farzan Solimani, Katharina Meier, Kamran Ghoreschi
    Studysummary This review discusses the immunological basis and development of Janus kinase inhibitors for treating skin diseases and reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 21

    1. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019
    2. Janus Kinase Inhibition in Down Syndrome: Two Cases of Therapeutic Benefit for Alopecia Areata JAAD case reports · 2019
    3. JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2019
    4. JAK Inhibitors and Alopecia Areata Lancet · 2019
    5. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018
    6. Rebound Effect Associated with JAK Inhibitor Use in the Treatment of Alopecia Areata Journal of the European Academy of Dermatology and Venereology · 2018
    7. Topical Tofacitinib Solution for the Treatment of Alopecia Areata Affecting Eyelashes JAAD Case Reports · 2018
    8. Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series Dermatologic therapy · 2018
    9. Simultaneous Improvement of Alopecia Universalis and Atopic Dermatitis in a Patient Treated with a JAK Inhibitor JAAD case reports · 2018
    10. Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology Journal of the American Academy of Dermatology · 2018
    11. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    12. Topical Janus Kinase Inhibitors for the Treatment of Pediatric Alopecia Areata Journal of the American Academy of Dermatology · 2017
    13. Tofacitinib for the Treatment of Alopecia Areata and Variants in Adolescents Journal of the American Academy of Dermatology · 2016
    14. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    15. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    16. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    17. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    18. Drug Delivery with Topically Applied Nanoparticles: Science Fiction or Reality? Skin pharmacology and physiology · 2013
    19. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    20. Graft-Versus-Host Disease: Comprehensive Overview by the American Academy of Dermatology Journal of the American Academy of Dermatology · 2012
    21. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010

    Related research 9

    1. Refractory Alopecia Universalis Associated with Dermatomyositis Successfully Treated with Tofacitinib Modern Rheumatology Case Reports · 2022
    2. Acne Exacerbation After Tofacitinib Treatment for Alopecia Areata Dermatology Reports · 2022
    3. Acne Exacerbation After Tofacitinib Treatment for Alopecia Areata Dermatology Reports · 2021
    4. Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata JCI insight · 2021
    5. Topical Tofacitinib in Treatment of Alopecia Areata Einstein (São Paulo) · 2020
    6. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019
    7. Comorbidities in Dermatology Dermatologic Clinics · 2018
    8. Role of Janus Kinase Inhibitors in the Treatment of Alopecia Areata Drug design, development and therapy · 2018
    9. Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib PubMed · 2018