Janus Kinase Inhibition in Down Syndrome: Two Cases of Therapeutic Benefit for Alopecia Areata

    April 2019 in “ JAAD case reports
    Angela L. Rachubinski, Belinda Enriquez Estrada, David A. Norris, Cory A. Dunnick, Jennifer C. Boldrick, Joaquín M. Espinosa
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    TLDR JAK inhibitors helped treat hair loss in two people with Down syndrome.
    The document discussed two cases where Janus kinase (JAK) inhibition showed therapeutic benefits for individuals with Down syndrome (DS) suffering from alopecia areata (AA). DS is associated with immune dysregulation and a higher risk of autoimmune conditions, partly due to the genetic cause, trisomy 21 (T21), which activates the interferon (IFN) response and hyperactivates JAK/STAT signaling. This leads to chronic autoinflammation and overexpression of IFN-stimulated genes. The study highlighted the potential of JAK inhibitors in managing AA in DS patients by targeting the underlying molecular mechanisms.
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      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

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