Janus Kinase Inhibitors in Dermatology: A Systematic Review

    Rony Shreberk‐Hassidim, Yuval Ramot, Abraham Zlotogorski
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    TLDR JAK inhibitors help with skin conditions but need more research on dosing and safety.
    This systematic review from 2017 evaluated the use of Janus kinase (JAK) inhibitors in dermatology by analyzing 134 articles, including 78 original articles and 18 clinical trials. JAK inhibitors showed beneficial results for psoriasis, comparable to etanercept, and favorable outcomes for alopecia areata. Preliminary positive results were also noted for vitiligo, dermatitis, graft versus host disease, cutaneous T cell lymphoma, and lupus erythematosus. The most common adverse events were infections, particularly nasopharyngitis and upper respiratory tract infections. However, the review highlighted gaps in knowledge regarding the correct dosing and safety profile of JAK inhibitors, indicating a need for further trials.
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