Janus Kinase Inhibitors in Dermatology: A Systematic Review

    February 2017 in “ Journal of the American Academy of Dermatology ”
    Rony Shreberk‐Hassidim, Yuval Ramot, Abraham Zlotogorski
    Studysummary This systematic review found that Janus kinase inhibitors have shown beneficial effects for psoriasis and alopecia areata, with promising preliminary results in other skin conditions, though more research is needed to define dosing and safety profiles.
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    Research cited in this study 16

    1. Tofacitinib for the Treatment of Alopecia Areata and Variants in Adolescents Journal of the American Academy of Dermatology · 2016
    2. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    3. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    4. Successful Treatment of Refractory Alopecia Areata Universalis and Psoriatic Arthritis, But Not Plaque Psoriasis with Tofacitinib in a Young Woman Acta dermato-venereologica · 2016
    5. Efficacy of Tofacitinib in Treatment of Alopecia Universalis in Two Patients Journal of the European Academy of Dermatology and Venereology · 2016
    6. Treatment of an Alopecia Areata Patient with Tofacitinib Results in Regrowth of Hair and Changes in Serum and Skin Biomarkers Experimental Dermatology · 2016
    7. Transient Efficacy of Tofacitinib in Alopecia Areata Universalis Case Reports in Dermatology · 2016
    8. A Systematic Review of Pulse Steroid Therapy for Alopecia Areata Journal of the American Academy of Dermatology · 2016
    9. Rapid Skin Repigmentation on Oral Ruxolitinib in a Patient with Coexistent Vitiligo and Alopecia Areata Journal of the American Academy of Dermatology · 2015
    10. Topical Ruxolitinib for the Treatment of Alopecia Universalis JAMA dermatology · 2015
    11. Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis JAMA Dermatology · 2015
    12. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    13. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    14. The Genetics Of Alopecia Areata: New Approaches, New Findings, New Treatments Journal of Dermatological Science · 2015
    15. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    16. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014

    Related research 4

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023
    2. Treatment With Oral Janus Kinase Inhibitors in Adult Patients With Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    3. Inhibiting Janus Kinases to Treat Alopecia Areata Nature medicine · 2014
    4. Recurrence of Alopecia Areata in a Patient Receiving Etanercept Injections Archives of Dermatology · 2005