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Glossary Chronic Inflammation

long-term immune response causing tissue damage and disease

Chronic inflammation, also known as persistent inflammation, is a prolonged and often harmful immune response that can last for months or even years. Unlike acute inflammation, which is a short-term response to injury or infection, chronic inflammation can result from ongoing exposure to irritants, autoimmune disorders, or unresolved acute inflammation. This persistent state can lead to tissue damage and is associated with various diseases, including arthritis, cardiovascular disease, and certain types of alopecia.

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Research

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research Evidence on Hidradenitis Suppurativa as an Autoinflammatory Skin Disease

9 citations , September 2024 in “Journal of Clinical Medicine”

This review examines the role of autoinflammation and immune dysregulation in hidradenitis suppurativa, linking it to genetic factors and autoinflammatory syndromes, but highlights the need for further research to fully understand its pathogenic mechanisms.

research Faculty Opinions recommendation of Hidradenitis suppurativa as a potential subtype of autoinflammatory keratinization disease.

December 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

This mini review discusses insights into the pathogenesis of hidradenitis suppurativa, highlighting genetic mutations, autoinflammation, and the effectiveness of biologics, and introduces the concept of autoinflammatory keratinization disease, without reporting new clinical results.

Janus Kinase Inhibition in Down Syndrome: Two Cases of Therapeutic Benefit for Alopecia Areata

research Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata

32 citations , April 2019 in “JAAD case reports”

This study discusses the immune dysregulation observed in individuals with Down syndrome, highlighting their increased risk for autoimmune skin conditions, but does not yet clarify the molecular mechanisms behind this profile.

research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease

41 citations , May 2020 in “Frontiers in immunology”

This review discusses the genetic, autoinflammatory, and keratinization factors involved in hidradenitis suppurativa and presents the concept of classifying it as an autoinflammatory keratinization disease, but reports no new clinical results.

research Acne Syndromes and Mosaicism

1 citations , November 2021 in “Biomedicines”

This review elaborates on the concept of cutaneous mosaicism and its link to acneiform conditions, but it reports no new clinical results.

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Community Join

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community Telogen Effluvium/Chronic TE and immune-related hair loss advice

5 upvotes 8 years ago

Chronic Telogen Effluvium can be managed by avoiding inflammatory foods, exercising, staying hydrated, and using supplements like krill oil, saw palmetto, or licorice root. Minoxidil is discouraged due to its cost and potential for worsening hair loss, while castor oil is recommended to strengthen hair roots and reduce shedding.

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 1 year ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

community Could Finasteride theoretically induce chronic telogen effluvium?

5 upvotes 1 year ago

A user experienced continuous hair shedding for 13 months after starting finasteride, suspecting it might cause chronic telogen effluvium, and considered switching to dutasteride or stopping medication. Other users suggested that finasteride doesn't cause hair loss, recommending dutasteride for more aggressive hair loss, while some advised against stopping medication.

community anti-androgens help with chronic seborric dermatitis ?! and hence diffuse thinning

7 upvotes 1 year ago

An 18-year-old experiencing hair loss and seborrheic dermatitis has tried finasteride, dutasteride, and various shampoos without success. They are considering anti-androgens like RU58841 and KX-826 for oil control and dandruff reduction.

community Low level chronic allergies and hair loss

5 upvotes 2 years ago

Hair loss can be influenced by chronic low-level allergies, and treatments like fexofenadine or topical cetirizine may help with regrowth. The user avoids finasteride, dutasteride, and minoxidil, and has tried Regenera Activa and PRF sessions.

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Learn

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learn Botox

Could Botox be the unexpected solution for chronic hair shedding? Botox may help reduce chronic hair shedding by improving scalp blood flow.

learn Folic acid

Is folic acid deficiency a common cause of chronic or sudden hair shedding? Folic acid deficiency can contribute to hair shedding but is not a common cause.

learn Vitamin B12

Is Vitamin B12 helpful for both men and women experiencing chronic hair shedding? Vitamin B12 may help with hair shedding only if there is a deficiency.

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Clinics

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