Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

    October 2019 in “ Dermatology and therapy
    Ana Montilla, Francisco Gómez-García, Pedro Jesús Gómez-Arias, Jesús Gay-Mimbrera, Jorge Hernández-Parada, Beatriz Isla-Tejera, Juan Ruano
    Image of study
    TLDR Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.
    The document reviewed the use of drugs targeting the JAK/STAT pathway for treating atopic dermatitis (AD), vitiligo, and alopecia areata (AA), diseases where this pathway plays a role in inflammation. As of April 2019, no drugs targeting this pathway had been approved for dermatological diseases. The review included 96 studies, with 66 on AA, 10 on vitiligo, and 20 on AD. Drugs such as tofacitinib and ruxolitinib were primarily used across all three diseases, with additional drugs tested for AD and AA. Results showed all AD patients improved, while responses in vitiligo and AA patients varied, including some unresponsive cases. The safety profiles of these drugs were generally mild or without adverse events. However, the evidence for the efficacy and safety of these drugs was still considered to be of low quality.
    Discuss this study in the Community →

    Research cited in this study

    66 / 66 results

    Related Community Posts Join

    6 / 47 results

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 2 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community What 3 months without fin& min does😔

      in Progress Pictures  261 upvotes 1 month ago
      Stopping minoxidil and finasteride for three months caused significant hair loss. The user resumed treatment with 2.5mg oral minoxidil and 0.6mg finasteride and plans to update on progress in three months.

      community No idea what's causing my hair thinning

      in Chat  2 upvotes 2 months ago
      The user is experiencing diffuse hair thinning despite using finasteride and oral minoxidil, with no hairline recession or bald spots. Suggestions include checking for telogen effluvium, considering a JAK inhibitor for potential autoimmune issues, and conducting further tests to rule out other causes.

      community DUPA - 20 YO - Non responder to everything

      in Finasteride/Dutasteride  13 upvotes 3 months ago
      A 20-year-old user experienced worsening hair loss despite using various treatments including topical and oral minoxidil, finasteride, and dutasteride. Other users suggested additional treatments like JAK inhibitors, RU58841, and lifestyle changes, but the user remains skeptical and frustrated.

    Related Research

    3 / 3 results