Scoping Review on the Use of Drugs Targeting JAK/STAT Pathway in Atopic Dermatitis, Vitiligo, and Alopecia Areata

    October 2019 in “ Dermatology and therapy ”
    Ana Montilla, Francisco Gómez-García, Pedro Jesús Gómez-Arias, Jesús Gay-Mimbrera, Jorge Hernández-Parada, Beatriz Isla-Tejera, Juan Ruano
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    TLDR Drugs targeting the JAK/STAT pathway can improve atopic dermatitis but vary in effectiveness for vitiligo and alopecia areata, with generally mild safety concerns.
    The document reviewed the use of drugs targeting the JAK/STAT pathway for treating atopic dermatitis (AD), vitiligo, and alopecia areata (AA), diseases where this pathway plays a role in inflammation. As of April 2019, no drugs targeting this pathway had been approved for dermatological diseases. The review included 96 studies, with 66 on AA, 10 on vitiligo, and 20 on AD. Drugs such as tofacitinib and ruxolitinib were primarily used across all three diseases, with additional drugs tested for AD and AA. Results showed all AD patients improved, while responses in vitiligo and AA patients varied, including some unresponsive cases. The safety profiles of these drugs were generally mild or without adverse events. However, the evidence for the efficacy and safety of these drugs was still considered to be of low quality.
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