Tofacitinib 2% Ointment, a Topical Janus Kinase Inhibitor, for the Treatment of Alopecia Areata: A Pilot Study of 10 Patients

    November 2017 in “ Journal of the American Academy of Dermatology ”
    Lucy Liu, Brittany G. Craiglow, Brett King
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    TLDR Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.
    In a 24-week pilot study involving 10 patients with alopecia areata (AA), the application of tofacitinib 2% ointment, a topical Janus kinase inhibitor, twice daily resulted in hair regrowth in 3 out of 10 subjects. The mean decrease in Severity of Alopecia Tool (SALT) score among these responders was 34.6%, with one patient showing a 61% improvement. However, the study also noted adverse events such as scalp skin irritation in 40% of patients and folliculitis in 10%, both of which resolved without treatment. Additionally, 40% of patients experienced a minimal elevation in total cholesterol. The study concluded that while the level of response to topical tofacitinib was less than that seen with oral tofacitinib, it was similar to that reported with clobetasol 0.05% ointment under occlusion. Further research was deemed necessary to better understand the treatment of AA with topical JAK inhibitors.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 9 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 10 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 4 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  1 upvotes 2 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 2 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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