Oral Tofacitinib: A Promising Treatment in Atopic Dermatitis, Alopecia Areata, and Vitiligo

    October 2017 in “ Clinical and Experimental Dermatology ”
    Mi Vu, Christopher Heyes, Susan J. Robertson, George Varigos, Gayle Ross
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    TLDR Oral tofacitinib shows promise in treating atopic dermatitis and alopecia areata, but only slight improvement in vitiligo.
    The document discussed a case where oral tofacitinib, a Janus kinase (JAK)-1/3 inhibitor, was used to treat a 44-year-old man with atopic dermatitis (AD), alopecia areata (AA), and vitiligo, which were refractory to other treatments. Tofacitinib is thought to benefit AD by downregulating the T helper 2 immune response and may also affect AA and vitiligo by downregulating interferon (IFN)-y signaling. The patient showed significant improvement in AD after 3 months, with a complete remission (Eczema Area and Severity Index (EASI) score from 14.4 to 0.0), and slow but continued improvement in AA with increased hair growth. However, only marginal improvement was observed in vitiligo (Vitiligo Area Scoring Index (VASI) score from 4.68 to 3.95). Tofacitinib was well tolerated with no serious adverse effects, although monitoring for potential side effects like hyperlipidemia, neutropenia, lymphopenia, anaemia, hepatitis, and elevated serum creatinine and creatine kinase levels was necessary. The case adds to the limited evidence supporting the use of tofacitinib in these conditions, but randomized controlled studies are needed to validate its efficacy.
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      in Chat  35 upvotes 10 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 3 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

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      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 1 week ago
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