Treatment of Alopecia Universalis with Topical Janus Kinase Inhibitors – A Double Blind, Placebo, and Active Controlled Pilot Study

    August 2018 in “ International Journal of Dermatology ”
    Laita Bokhari, Rodney Sinclair
    Studysummary In this phase I study, partial hair regrowth was observed in patients with alopecia universalis using topical JAK inhibitors, though more research is needed to confirm potential as a treatment alternative to clobetasol.
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    Research cited in this study 14

    1. JAK Inhibitors in Dermatology: The Promise of a New Drug Class Journal of the American Academy of Dermatology · 2017
    2. Tofacitinib for the Treatment of Alopecia Areata and Variants in Adolescents Journal of the American Academy of Dermatology · 2016
    3. Transient Efficacy of Tofacitinib in Alopecia Areata Universalis Case Reports in Dermatology · 2016
    4. Alopecia Areata: Overview and Treatment Options Current problems in dermatology · 2015
    5. Inhibiting Janus Kinases to Treat Alopecia Areata Nature medicine · 2014
    6. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    7. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    8. Alopecia Areata With White Hair Regrowth: Case Report and Review of Poliosis Dermatology online journal · 2014
    9. Alopecia Areata: Updates from the Mouse Perspective ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2013
    10. Alopecia Areata: An Update Indian Journal of Dermatology, Venereology and Leprology · 2013
    11. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    12. A Case of Widespread Non-Pigmented Hair Regrowth in Diffuse Alopecia Areata Australasian Journal of Dermatology · 2007
    13. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    14. Persistent Depigmented Regrowth After Alopecia Areata Journal of the American Academy of Dermatology · 2002

    Related research 1

    1. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients International Journal of Trichology · 2018