Drugs Targeting the JAK/STAT Pathway for the Treatment of Immune-Mediated Inflammatory Skin Diseases: Protocol for a Scoping Review

The document described a protocol for a scoping review to evaluate the evidence on JAK/STAT pathway-targeting drugs for treating immune-mediated inflammatory skin diseases, including alopecia areata. At the time, no JAK/STAT inhibitors were approved for skin disease treatment, despite their potential. The review aimed to systematically gather and summarize existing research, identify knowledge gaps, and formulate new research questions regarding these drugs' indications, mechanisms, efficacy, and safety. The study highlighted the importance of evidence-based medicine and aimed to improve decision-making in dermatology. The results were intended to provide insights into the use of JAK/STAT inhibitors and guide future research.