Drugs Targeting the JAK/STAT Pathway for the Treatment of Immune-Mediated Inflammatory Skin Diseases: Protocol for a Scoping Review

May 2019 in “ BMJ Open ”

Francisco J. García, Pedro Jesús Gómez‐Arias, Jorge A. Hernández, Ana Montilla, Jesús Gay-Mimbrera, Macarena Aguilar-Luque, Isabel Viguera-Guerra, Antonio Vélez García‐Nieto, Beatriz Isla-Tejera, Juan Ruano

JAK/STAT pathway JAK/STAT inhibitors psoriasis atopic dermatitis alopecia areata vitiligo melanoma

TLDR JAK/STAT inhibitors show promise for skin diseases but aren't yet approved.

The document described a protocol for a scoping review to evaluate the evidence on JAK/STAT pathway-targeting drugs for treating immune-mediated inflammatory skin diseases, including alopecia areata. At the time, no JAK/STAT inhibitors were approved for skin disease treatment, despite their potential. The review aimed to systematically gather and summarize existing research, identify knowledge gaps, and formulate new research questions regarding these drugs' indications, mechanisms, efficacy, and safety. The study highlighted the importance of evidence-based medicine and aimed to improve decision-making in dermatology. The results were intended to provide insights into the use of JAK/STAT inhibitors and guide future research.

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Research cited in this study

3 / 3 results

research Janus Kinase Inhibitors in Dermatology: A Systematic Review

116 citations , February 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors help with skin conditions but need more research on dosing and safety.

research JAK Inhibitors in Dermatology: The Promise of a New Drug Class

355 citations , January 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.

research Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature

40 citations , December 2016 in “Journal of Dermatological Treatment”

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

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in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community What else is good. Besides the big 3.

in Chat 35 upvotes 1 year ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

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PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community What 3 months without fin& min does😔

in Progress Pictures 261 upvotes 1 year ago

Stopping minoxidil and finasteride for three months caused significant hair loss. The user resumed treatment with 2.5mg oral minoxidil and 0.6mg finasteride and plans to update on progress in three months.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

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The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community No idea what's causing my hair thinning

in Chat 2 upvotes 1 year ago

The user is experiencing diffuse hair thinning despite using finasteride and oral minoxidil, with no hairline recession or bald spots. Suggestions include checking for telogen effluvium, considering a JAK inhibitor for potential autoimmune issues, and conducting further tests to rule out other causes.

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