Tofacitinib helped a woman with total-body hair loss grow her hair back.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Machine learning can predict how well patients with alopecia areata will respond to certain treatments.
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November 2021 in “Signal Transduction and Targeted Therapy” The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
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May 2019 in “BMJ Open” The document outlined a protocol for a scoping review to evaluate the evidence on drugs targeting the JAK/STAT pathway for treating dermatological diseases such as psoriasis, atopic dermatitis, alopecia areata, vitiligo, and melanoma. Despite the growing evidence of JAK/STAT inhibitors' potential in dermatology, none had been approved for skin disease treatment at the time. The review aimed to systematically gather and analyze existing studies using a five-stage methodology from the Joanna Briggs Institute, with results to be reported following the PRISMA-ScR guidelines. The findings were intended for dissemination through peer-reviewed publications and conference presentations.
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January 2020 in “Mediterranean Journal of Rheumatology” New JAK inhibitor drugs show promise for treating skin diseases but need more research on safety and effectiveness.