JAK Inhibitors for Treatment of Alopecia Areata

    July 2018 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Eddy H.C. Wang, B. Sallee, Christina I. Tejeda, Angela M. Christiano
    TLDR JAK inhibitors can effectively reverse hair loss in people with alopecia areata.
    The document reviewed the use of Janus kinase (JAK) inhibitors, such as tofacitinib and ruxolitinib, for treating alopecia areata (AA), an autoimmune condition causing hair loss. Clinical trials and case reports demonstrated significant hair regrowth in patients with moderate to severe AA, with response rates ranging from 67% to 75%. However, hair loss often recurred after stopping the medication, and potential side effects like increased cancer risk and infections highlighted the need for safer formulations. The findings suggested that JAK inhibitors could be a promising therapeutic option, but further research was needed to confirm long-term safety and efficacy.
    Discuss this study in the Community →

    Research cited in this study

    30 / 30 results

    Related Community Posts Join

    6 / 45 results

      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community 8 months apart on the mother of all stacks

      in Progress Pictures  151 upvotes 1 year ago
      User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

      community DUPA - 20 YO - Non responder to everything

      in Finasteride/Dutasteride  13 upvotes 2 months ago
      A 20-year-old user experienced worsening hair loss despite using various treatments including topical and oral minoxidil, finasteride, and dutasteride. Other users suggested additional treatments like JAK inhibitors, RU58841, and lifestyle changes, but the user remains skeptical and frustrated.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

    Related Research

    3 / 3 results