An Open Label Clinical Trial of the JAK Inhibitor Tofacitinib for Alopecia Areata

    April 2017 in “ Journal of Investigative Dermatology ”
    Ali Jabbari, Jane Cerise, J.C. Chen, Freda Sansaricq, Raphael Clynes, Angela M. Christiano, Julian Mackay‐Wiggan
    Image of study
    TLDR Tofacitinib helped over half of the patients with severe hair loss regrow at least 50% of their hair.
    In a 2017 open-label clinical trial, the JAK inhibitor tofacitinib was tested on 12 patients with moderate to severe alopecia areata (AA), with 11 completing the study. The initial dosage of 5mg twice daily was increased to 10mg when responses were limited. The trial concluded that 7 out of the 12 patients experienced at least 50% hair regrowth, translating to a 60% response rate for the primary outcome. RNA sequencing from scalp biopsies indicated that molecular responses could be detected as early as 4 weeks into treatment, and gene expression profiles could predict which patients would not respond to the treatment before it commenced. These results suggest that tofacitinib could be an effective treatment for AA and highlight the need for larger clinical trials.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 15 results
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      by MagicBold in Research  865 upvotes 1 year ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 1 year ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       8 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

      community Xeljanz....the magic drug!!!

       2 upvotes 7 years ago
      A user experienced significant hair regrowth from Xeljanz after severe alopecia but can no longer afford it. They are seeking ways to obtain the medication despite its high cost and potential side effects.

      community can someone help me identify these pls

      in Treatment 3 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

      community DUPA, Non Responders and Connective Tissue Disorders

      in Research/Science  9 upvotes 9 months ago
      A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

    Related Research

    1 / 1 results