Treatment of Severe Alopecia Areata with the Oral Janus Kinase Inhibitor, Tofacitinib: A Retrospective Chart Review

    April 2017 in “ Journal of Investigative Dermatology ”
    Omer Ibrahim, Sara Hogan, Melissa Piliang, Wilma F. Bergfeld
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    TLDR Tofacitinib may help regrow hair in severe alopecia areata, but results differ greatly between people.
    The document detailed a retrospective study evaluating the effectiveness and safety of tofacitinib, a Janus kinase inhibitor, in treating 13 patients with long-standing, treatment-resistant moderate to severe alopecia areata. These patients had an average of 93% scalp hair loss and had not responded to previous therapies. After treatment with tofacitinib, hair regrowth varied significantly among patients, ranging from 2% to 90%, with an average regrowth of 44.3% and a median of 50.5%. The study concluded that tofacitinib could be effective for patients with over 75% hair loss, but results varied widely. It was suggested that treatment trials should last at least 4 months to a year to adequately evaluate the drug's efficacy.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 9 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 9 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 3 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  1 upvotes 2 days ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 3 days ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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