Topical Tofacitinib Solution for the Treatment of Alopecia Areata Affecting Eyelashes

The document reports a successful case of treating alopecia areata (AA) affecting the eyelashes with topical tofacitinib 2% solution. A female patient in her late 20s with an 11-month history of left upper eyelash loss, who had not responded to previous treatments, experienced near-complete regrowth of her eyelashes after 4 months of using the solution twice daily. She continued to maintain this regrowth at 7 months, reducing the application frequency to once daily without any adverse effects. This case suggests that while topical Janus kinase (JAK) inhibitors may not be practical for extensive AA, they could be effective for localized AA, especially when traditional treatments fail. The document also notes that ongoing clinical trials are investigating the safety and efficacy of topical JAK inhibitors for AA treatment.