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    Glossary Janus Kinase Inhibitors

    medications that block enzymes involved in immune response signaling

    Janus Kinase Inhibitors, often referred to as JAK inhibitors, are a class of medications that block the activity of Janus kinases, which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage conditions like rheumatoid arthritis, psoriasis, and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    1. Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata JAAD case reports · 2019 · 32 citations
    2. Janus kinase inhibition for the treatment of refractory frontal fibrosing alopecia: A case series and review of the literature JAAD Case Reports · 2023 · 16 citations
    3. Selective Janus kinase 1 inhibition resolves inflammation and restores hair growth offering a viable treatment option for alopecia areata Skin health and disease · 2023 · 4 citations
    4. A review of Janus kinase inhibitor use in scarring alopecia JAAD reviews. · 2025 · 4 citations
    5. 0527 Effectiveness of janus kinase inhibitor for rapidly progressive acute alopecia areata Journal of Investigative Dermatology · 2026
    6. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    7. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    8. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    9. Exploring the efficacy of baricitinib in treating alopecia areata after failed Janus kinase inhibitor therapy JAAD Case Reports · 2023 · 7 citations
    10. Relapse of alopecia areata during ongoing Janus kinase inhibitor therapy is not uncommon and usually occurs in previously affected areas: A multicenter Italian real-world study Journal of the American Academy of Dermatology · 2026
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    Learn 3

    1. Tofacitinib JAK inhibitor pill, an immune-system drug
    2. Baricitinib JAK inhibitor pill used for severe alopecia areata
    3. Alopecia Areata autoimmune disorder causing patchy hair loss

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