Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases

    August 2019 in “ Frontiers in immunology ”
    Kata Szilveszter, Tamás Németh, Attila Mócsai
    TLDR Tyrosine kinases are important in skin autoimmune diseases and could be targets for new treatments.
    The document reviewed the role of tyrosine kinases in autoimmune and inflammatory skin diseases, emphasizing the therapeutic potential of kinase inhibitors. It highlighted the effectiveness of JAK inhibitors, such as tofacitinib and ruxolitinib, in treating conditions like alopecia areata, vitiligo, and psoriasis, showing promising results in hair regrowth and symptom reduction. The review also discussed the role of SYK and other kinases in diseases like bullous pemphigoid, where autoantibodies and cytokines contribute to inflammation and tissue damage. Overall, targeting specific kinases was suggested as a significant advancement in treating these skin conditions.
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