Drug Delivery with Topically Applied Nanoparticles: Science Fiction or Reality?

    January 2013 in “ Skin pharmacology and physiology ”
    Jürgen Lademann, Heike Richter, Martina C. Meinke … Alexa Patzelt
    Studysummary This article reviews the potential of nanoparticles for drug delivery through the skin barrier and highlights the need for further research on solid nanoparticles, as they lack commercial development for this purpose.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on karger.com →
    Discuss this study in the Community →

    Research cited in this study 15

    1. Skin Permeation of Small-Molecule Drugs, Macromolecules, and Nanoparticles Mediated by a Fractional Carbon Dioxide Laser: The Role of Hair Follicles Pharmaceutical research · 2012
    2. Triggering of Drug Release of Particles in Hair Follicles Journal of controlled release · 2012
    3. The In Vitro Use of the Hair Follicle Closure Technique to Study the Follicular and Percutaneous Permeation of Topically Applied Drugs ATLA. Alternatives to laboratory animals · 2012
    4. Non-Invasive Analysis of Penetration and Storage of Isoconazole Nitrate in the Stratum Corneum and Hair Follicles European Journal of Pharmaceutics and Biopharmaceutics · 2012
    5. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    6. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    7. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    8. Focus on Skin as a Possible Port of Entry for Solid Nanoparticles and the Toxicological Impact Journal of biomedical nanotechnology · 2010
    9. Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam European Journal of Pharmaceutics and Biopharmaceutics · 2010
    10. Targeting to the Hair Follicles: Current Status and Potential Journal of dermatological science · 2010
    11. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    12. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    13. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    14. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    15. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004