Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles

    July 2023 in “ Pharmaceutics (Basel) ”
    Maíra N. Pereira, Luma L. Nogueira, Marcílio Cunha-Filho … Guilherme M. Gelfuso
    Studysummary This study reviews various skin models and methodologies used to assess the follicular penetration of nanoparticle-based drugs, highlighting inconsistencies that complicate comparisons and aims to establish more uniform protocols for clearer study outcomes.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 40

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders Asian Journal of Pharmaceutical Sciences · 2022
    3. Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia European Journal of Pharmaceutics and Biopharmaceutics · 2022
    4. Nanostructured Drug Delivery Systems for Targeting 5-Alpha-Reductase Inhibitors to the Hair Follicle Pharmaceutics · 2022
    5. Follicular-Targeted Delivery of Spironolactone Provided by Polymeric Nanoparticles Colloids and surfaces. B, Biointerfaces · 2021
    6. Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications Frontiers in Bioengineering and Biotechnology · 2021
    7. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    8. Thiolated and PEGylated Silica Nanoparticle Delivery to Hair Follicles International journal of pharmaceutics · 2020
    9. Latanoprost Loaded in Polymeric Nanocapsules for Effective Topical Treatment of Alopecia AAPS PharmSciTech · 2020
    10. The Influence of Sebaceous Content on the Performance of Nanosystems Designed for the Treatment of Follicular Diseases Journal of Drug Delivery Science and Technology · 2020
    11. LC-MS Bioanalytical Method for Simultaneous Determination of Latanoprost and Minoxidil in the Skin Journal of Pharmaceutical and Biomedical Analysis · 2020
    12. Dutasteride Nanocapsules for Hair Follicle Targeting: Effect of Chitosan-Coating and Physical Stimulus International Journal of Biological Macromolecules · 2020
    13. Solvent-Containing Closure Material Prevents Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin Skin Pharmacology and Physiology · 2020
    14. Transdermal Delivery of Minoxidil Using HA-PLGA Nanoparticles for the Treatment of Alopecia Biomaterials Research · 2019
    15. Caffeic Acid Skin Absorption: Delivery of Microparticles to Hair Follicles Saudi pharmaceutical journal · 2019
    16. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    17. Minoxidil-Encapsulated Poly(L-Lactide-Co-Glycolide) Nanoparticles with Hair Follicle Delivery Properties Prepared Using Solvent Evaporation and Sonication Bio-medical Materials and Engineering · 2018
    18. Selective Delivery of Adapalene to the Human Hair Follicle Under Finite Dose Conditions Using Polymeric Micelle Nanocarriers Nanoscale · 2017
    19. Transdermal Permeation of Drugs in Various Animal Species Pharmaceutics · 2017
    20. Investigation of the Cutaneous Penetration Behavior of Dexamethasone Loaded to Nano-Sized Lipid Particles by EPR Spectroscopy, and Confocal Raman and Laser Scanning Microscopy European journal of pharmaceutics and biopharmaceutics · 2016
    21. Development and Characterization of Polymeric Nanoparticle-Based Formulation of Adapalene for Topical Acne Therapy Nanomedicine · 2016
    22. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    23. Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle Nanoscale · 2015
    24. Delivery and Targeting of Nanoparticles into Hair Follicles Therapeutic Delivery · 2014
    25. Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis Molecular pharmaceutics · 2014
    26. Cutaneous Drug Delivery: An Update Journal of Investigative Dermatology Symposium Proceedings · 2013
    27. Investigation of Follicular and Non-Follicular Pathways for Polyarginine and Oleic Acid-Modified Nanoparticles Pharmaceutical research · 2012
    28. Advanced Chemical Imaging and Comparison of Human and Porcine Hair Follicles for Drug Delivery by Confocal Raman Microscopy Journal of Biomedical Optics · 2012
    29. The In Vitro Use of the Hair Follicle Closure Technique to Study the Follicular and Percutaneous Permeation of Topically Applied Drugs ATLA. Alternatives to laboratory animals · 2012
    30. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    31. Follicular and Percutaneous Penetration Pathways of Topically Applied Minoxidil Foam European Journal of Pharmaceutics and Biopharmaceutics · 2010
    32. Targeting to the Hair Follicles: Current Status and Potential Journal of dermatological science · 2010
    33. Biology of Human Hair: Know Your Hair to Control It Advances in Biochemical Engineering / Biotechnology · 2010
    34. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    35. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    36. Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005
    37. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of controlled release · 2004
    38. Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles Journal of Controlled Release · 2004
    39. Permeant Lipophilicity and Vehicle Composition Influence Accumulation of Dyes in Hair Follicles of Human Skin European journal of pharmaceutical sciences · 2003
    40. Distribution of Human Hair in Follicular Units Dermatologic Surgery · 1999