Advanced Chemical Imaging and Comparison of Human and Porcine Hair Follicles for Drug Delivery by Confocal Raman Microscopy

    November 2012 in “ Journal of Biomedical Optics ”
    Lutz Franzen, Christiane Mathes, Steffi Hansen, Maike Windbergs
    TLDR Confocal Raman microscopy can effectively study drug delivery in hair follicles using pig ear models.
    The study utilized confocal Raman microscopy to compare the chemical composition of human and porcine hair follicles, confirming optical similarity between the two species. This technique, combined with optical profilometry, provided a novel method for analyzing follicular penetration and component distribution in three dimensions. The research demonstrated that confocal Raman microscopy had significant potential as a noninvasive and chemically selective method for studying trans-follicular drug delivery, with excised pig ear serving as a reliable in vitro model for evaluating drug penetration into hair follicles.
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