Follicular Penetration of Nano-Sized Particulate FA-PLGA and the Dye RhBITC in Dorsal Dog and Rat Skin, and Porcine Ear Skin as an In Vitro Model for the Human Integument

January 2011

Fanny Knorr

nano-sized particles FA-PLGA RhBITC hair follicles porcine skin differential stripping method localized drug delivery follicular structure

TLDR Hair follicles can effectively absorb nano-sized particles, making them potential targets for localized drug delivery.

This study investigated the penetration of nano-sized FA-PLGA particles into hair follicles of excised dog, rat, and porcine skin, with porcine skin serving as a model for human skin. The research found that 60-70% of hair follicles in all samples were receptive to penetration, with deeper penetration in porcine follicles due to their larger openings and longer infundibula. The study also explored the quantification of the dye RhBITC in porcine follicles, finding that 5% of the applied dye could be extracted, supporting the efficacy of the modified differential stripping method. The study highlighted the potential of hair follicles as reservoirs for drug delivery, although no significant influence of particle size on penetration was observed.

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