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Glossary Differential Stripping

technique selectively removes specific layers for detailed analysis

Differential Stripping is a technique used in the study of hair and skin to selectively remove specific layers or components. This method allows researchers to analyze the structure and composition of different layers, such as the cuticle, cortex, and medulla in hair, or the epidermis and dermis in skin, to better understand their individual properties and functions.

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5 / 1000+ results

research Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles

4 citations , July 2023 in “Pharmaceutics (Basel)”

This study reviews various skin models and methodologies used to assess the follicular penetration of nanoparticle-based drugs, highlighting inconsistencies that complicate comparisons and aims to establish more uniform protocols for clearer study outcomes.

research Methods for quantifying intrafollicular drug delivery: a critical appraisal

34 citations , July 2010 in “Expert Opinion on Drug Delivery”

This review highlights the need for methodologies to understand and quantify drug penetration into hair follicles as significant drug pathways, noting this area lacks comprehensive articles and reports no new results.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study introduces a novel non-invasive method called "differential stripping" to quantify the penetration of topically applied substances into hair follicles.

research Follicular penetration of nano-sized particulate FA-PLGA and the dye RhBITC in dorsal dog and rat skin, and porcine ear skin as an in vitro model for the human integument

January 2011

In this study, penetration of FA-PLGA nanoparticles into hair follicles was observed in excised dog, rat, and porcine skin, with the deepest penetration in porcine skin, suggesting its similarity to human skin for drug delivery studies.

research Targeting to the hair follicles: Current status and potential

142 citations , January 2010 in “Journal of dermatological science”

This review covers follicle-targeting drug delivery systems, exploring their potential for improving localized and systemic therapies, and highlights the need for further research into follicle penetration mechanisms.

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community What do you guys think about my foundation?

8 months ago

The user had a hair transplant and uses oral minoxidil, a red laser therapy helmet, fish oil, collagen, and sardines for hair thinning but avoids finasteride due to side effect concerns. Many suggest these methods may not be effective long-term without a DHT blocker.

community Dear Dutasteride users, Yes or no?

in Finasteride/Dutasteride 31 upvotes 9 months ago

Dutasteride is often more effective than finasteride for hair regrowth, though it may cause initial shedding. Many users see positive results after several months, with some combining it with minoxidil for better outcomes.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Temporalis Hypertrophy and hair loss

in Treatment 24 upvotes 1 year ago

Hair loss treatments include finasteride, minoxidil, and scalp exercises. Opinions vary on the effectiveness, with some attributing hair loss to muscle tension and inflammation, while others focus on genetics and DHT.

community Hair regrowth without drugs (99% natural) 25M

528 upvotes 4 months ago

A user shared their experience with hair regrowth using supplements like NAC and DIM, and briefly using minoxidil with microneedling. They reported some improvement in hair density, but the community questioned the effectiveness compared to traditional treatments like finasteride.

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