Investigation of Transfollicular Caffeine Penetration Using Microdialysis on Ex Vivo Porcine Ear Skin

    October 2020 in “ European journal of pharmaceutics and biopharmaceutics ”
    Anna Lena Klein, Markus Lubda, Per Stahl Skov … Alexa Patzelt
    Studysummary This study reported that combining microdialysis and selective follicular closure with varnish significantly reduces caffeine penetration through hair follicles in an ex vivo porcine ear skin model.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Solvent-Containing Closure Material Prevents Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin Skin Pharmacology and Physiology · 2020
    2. Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In Vitro Human Skin Studies Skin pharmacology and physiology · 2018
    3. Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study Pharmaceutical research · 2017
    4. Contribution of the Hair Follicular Pathway to Total Skin Permeation of Topically Applied and Exposed Chemicals Pharmaceutics · 2016
    5. Analysis of Hair Follicle Penetration of Lidocaine and Fluorescein Isothiocyanate-Dextran 4 kDa Using Hair Follicle-Plugging Method Drug Development and Industrial Pharmacy · 2013
    6. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    7. The In Vitro Use of the Hair Follicle Closure Technique to Study the Follicular and Percutaneous Permeation of Topically Applied Drugs ATLA. Alternatives to laboratory animals · 2012
    8. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    9. Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2011
    10. Permeation of Topically Applied Caffeine Through Human Skin – A Comparison of In Vivo and In Vitro Data BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2009
    11. The Role of Hair Follicles in the Percutaneous Absorption of Caffeine BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology · 2007
    12. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    13. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004